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SCIENTIFIC PROGRAM

AUDITORIUM I - ROOM

  • 16:30 - 17:00 ESACT 2022 Opening Session
    Paula Alves (ESACT)
    17:00-18:00

    ESACT Innovation Award Lecture
    Presented by Terry Papoutsakis, Chair of the ESACT Innovation Award
    Committee (ESACT Honorary Member & University of Delaware, USA)

    ESACT Innovation Award Committee is pleased to present the 2022 awardees:
    Richard Wales and Neil Bargh for innovation in automated cell cultures technologies to support the development of biotherapeutics

    ESACT Innovation Award Lecture:

    Ambr15; how it happened and what was important

    18:00 – 19:20

    Scientific Session: Bio breakthroughs
    Chairs:
    Luís Almeida, CNC Univ de Coimbra, Portugal              
    Laura Cervera, Univ Autònoma Barcelona, Spain

    18:00-18:20

    INV 1 - Manipulating exosome biogenesis to enhance productivity of recombinant cell lines producing engineered exosome therapeutics
    Scott Estes, Codiak BioSciences, United States

    18:20-18:40  

    INV 2 - Innovating the Manufacturing of Human Mesenchymal Stromal Cells (MSC) and MSC-derived Products through Bioengineering
    Claudia Lobato da Silva, IBB, IST, Univ de LSiboa, Portugal

    18:40-18:50  

    O 1 - Preservation of critical quality attributes in 3D bioprinted cell-based structures by using natural hydrogels
    Joaquim Vives, Banc de Sang i Teixits, Spain

    18:50-19:00  

    O 2 - Turning an old medicine into a new therapeutical candidate: from erythropoietin to a novel hyperglycosylated, non-erythropoietic but neuroprotective analogue
    Marcos Oggero, UNL, CONICET, FBCB, Centro Biotecnológico del Litoral/BioSynaptica SA, Argentina

    19:00-19:10 

    O 3 - Systems-level discovery of quality attributes and candidate pathways for optimized production of human pluripotent stem cell-derived cardiomyocytes
    Aaron Simons, NSF ERC for Cell Manufacturing Technologies (CMaT), United States

    19:10-19:20 

    O 4 - Human stem-cell based models to study innate immunity and neuroinflammation in the central nervous system
    Catarina Gomes, iBET, Instituto de Biologia Experimental e Tecnológica, Portugal

    19:20 – 19:45

    Exhibitors Reception at the Exhibition Hall

    Introduction to The Porto wine
    by Vasco Magalhães (Wine expert) & Teresa Gomes (Sommelier) & tasting
    Cocktal reception

  • 9:00 - 10:00 Keynote Lecture
    Botond Roska, Institute of Molecular and Clinical Ophthalmology Basel (IOB), Switzerland
    Restoring vision using optogenetic therapy
    10:00 - 10:35

    Poster Student Highlights
    Chairpersons:

    Nusa Pristovsek, ESACT Frontiers & Novo Nordisk, Denmark
    Claire Pearce, ESACT Frontiers & XAP Therapeutics, UK
    Francisca Arez, iBET, Portugal

    H1
    - 3D Bioprinted Cellular Structures for Universal Production of Therapeutics
    Laura Chastagnier, 3d.Fab – ICBMS, France

    H2 - Semi-continuous propagation of influenza A virus and its defective interfering particles: Analyzing the dynamic competition to select antiviral candidates
    Lars Pelz, Max Planck Institute for Dynamics of Complex Technical Systems, Germany

    H3 - Extracellular Vesicles packaging and delivery of silencing sequences to alleviate a brain disorder
    David Rufino-Ramos, CNC - Center for Neuroscience and Cell Biology of University of Coimbra, Portugal

    H4 - Single-cell and Bulk RNA sequencing of insect Sf9 cells during rAAV production
    Nikolaus Virgolini, iBET - Instituto de Biologia Experimental e Tecnológica, Portugal

    H5 - Reverse genetics for Influenza A virus to generate genetically engineered defective interfering particles for antiviral treatment and vaccination
    Tanya Dogra, Max Planck Institute for Dynamics of Complex Technical Systems, Germany

    H6 - Investigating “Difficult-to-Express” mAb Frameworks in Transient and Site-Specific Integration-Based CHO Expression Systems
    Alana C. Szkodny, University of Delaware, United States

    H7 - Artificial miRNAs allow stepwise adjustment of core-fucosylation in CHO cells
    Patrick Schlossbauer, Biberach University of Applied Sciences, Germany

    H8 - Raman spectroscopy for monitoring of amino acids and antibody glycosylation in high cell density perfusion culture
    Hubert Schwarz, Competence Centre for Advanced BioProduction Continuous Processing (AdBIOPRO), Royal Institute of Technology (KTH), Sweden

    H9 - Lectin-aided flow cytometry reveals a close correlation between cell surface and mAb glycosylation
    Mina Ghahremanzamaneh, School of Chemical and Bioprocess Engineering, University College Dublin, Republic of Ireland

    H10 - Development of novel fast-growing Chinese hamster lung (CHL)-YN cells in serum-free fed-batch for monoclonal antibody production
    Puriwat Sukwattananipaat, Graduate School of Engineering, Osaka University, Japan

    H11 - Downstream process design and optimization of GAG HIV-1 based Virus-Like Particles
    Elianet Lorenzo Romero, Universitat Autònoma de Barcelona, Spain

    10:35 - 11:00 Coffee Break at Exhibition
    11:00 – 12:30

    Scientific Session: Data, Data, Data: how to get it and how to use it
    Chairpersons:
    Mike Betenbaugh, John Hopkins Univ, USA
    Damian Marshal, Achilles Therapeutics UK limited, UK

    11:00-11:25

    INV 3 - What can extracellular data tell us about intracellular pathways?
    Cleo Kontoravdi, Imperial College London, United Kingdom

    11:25-11:50

    INV 4 - Bioprocessing in the Digital Age: from Process Models, through the Integration of Machine Learning, to Digital Twins
    Alessandro Butté, DataHow AG, Switzerland

    11:50-12:03

    O 6 – Biomarker identification for in silico performance prediction of CHO cell lines expressing complex therapeutic Abs
    Stylianiv Papadaki, Roche Diagnostics GmbH, Germany

    12:03-12:16

    O 7 – On Digital Bioprocessing and Manufacturing Intelligence: Application of Process Analytical Technology and data analytics for upstream process development and intensification
    Ricardo Suarez Heredia, University College London/University of Cambridge/Merck KGaA, United Kingdom

    12:16-12:29

    O 8 – Bioprocess digital twins for biomanufacturing 4.0
    Dong-Yup Lee, SungKyunKwan University, Korea (South, Republic of)

    12:30 - 14:30 Lunch at Lunch Hall Dessert and coffee (will be served at Exhibition Hall)
    14:30-16:00 Poster Session I (at Exhibition Hall)
    16:00 – 17:30

    Scientific Session: Beyond Evolution
    Chairpersons:
    Martin Fussenegger (ETH, Switzerland)
    Nick Timmins (Artisan Bio, USA)

    16:00-16:30

    INV 5 - CAR T-cell immunotherapy of solid tumours: Parallel learning from the clinic and lab
    John Maher King´s College London, United Kingdom

    16:30-16:40

    O 9 – Blueprint from nature: Multi-omics comparison of CHO and plasma cells unveils novel cell engineering targets to improve productivity
    Nikolas Zeh, Boehringer Ingelheim Pharma GmbH, Germany

    16:40-16:50

    O 10 – Enabling large therapeutic gene delivery: improving dual AAV vector-intein mediated systems
    Mariana Ferreira, ITQB NOVA & iBET, Portugal

    16:50-17:00

    O 11 – Theranostic cells for detection and counteraction of infections by rewiring cellular host defense pathways
    Dagmar Wirth, Helmholtz Centre for Infection Research, Germany

    17:00-17:10

    O 12 – Viral protease-based molecular switches for drug discovery and synthetic biology applications
    Nik Franko, ETHZ, Switzerland

    17:10-17:15

    Flash 1 – Expanding The Design Space of Synthetic Promoters for CHO Cell Engineering Using Next-Generation Sequencing
    Adrian Bourke, University of Sheffield, United Kingdom

    17:15-17:20

    Flash 2 – Multiplexed engineering CHO cells to produce recombinant IgGs with desirable N-glycans via targeted integration
    Nguyen Tran Bich Ngan, Bioprocessing Technology Institute, A*STAR, Singapore

    17:30 - 18:00 Coffee Break at Exhibition
    18:00 – 19:30

    Scientific Session: Molecular Cell Surgery
    Chairpersons:
    Isabelle Rivière, Memorial Sloan Kettering Cancer Center, USA
    Nicole Borth, BOKU, Austria

    18:00-18:25

    INV 6  - Turning Genes into Medicines: Prospects and Problems in Development of a Novel Class of Therapeutics
    Kathy High, AskBio, Therapeutics, United States

    18:25-18:50

    INV 7 - Guiding mRNA-LNP drug products from early R&D programs to the market – Scale up and production of mRNA LNPs
    Andreas Wagner, Polymun Scientific, Austria

    18:50-19:00

    O 13 – Repairing the repairers: Stabilizing the CHO genome and protein production by editing DNA repair
    Nathan Lewis, University of California, San Diego, United States

    19:00-19:10

    O 14 – Influenza A virus-derived defective interfering particles for antiviral treatment
    Sascha Kupke, Max Planck Institute for Dynamics of Complex Technical Systems, Germany

    19:10-19:20

    O 15 – An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells
    Niels Bauer, Roche Diagnostics GmbH, Germany

    19:20-19:25

    Flash 3 – Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease
    Sara Lopes, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal

    19:25-19:30

    Flash 4 – Rational development of recombinant CHO cells based on histone analysis: Identification and experimental validation of stable integration sites
    Oliver Hertel, Bielefeld University, Germany

    19:30-21:00 Poster Viewing plus drinks (at Exhibition Hall)
  • 9:00 - 10:00 Keynote Lecture
    Hildegard Büning, Hannover Medical School, Germany
    Gene Therapy - a new class of medicine
     10:00 - 10:30

    Selected Flash Presentations Session

    Chairpersons:  

    Emma Petiot, 3d.FAB/UCBL, France

    Niall Barron,  NIBRT, Ireland



    Flash 5 –
    4-1BB and 4-1BBxOX40 bispecific Anticalin®-based payloads to armor cellular immunotherapies for effective localized immune cell stimulation
    Janet Peper-Gabriel, Pieris Pharmaceuticals GmbH, Germany

    Flash 6 – Culture of Pluripotent Stem Cells and Derivation of Organoids using Droplet Microfluidics
    Sebastien Sart, Institut Pasteur, France

    Flash 7 – Augmented decision making for cell culture process development: from data traceability & accessibility to process modelling
    Wolfgang Paul, Upstream Process Sciences Biotech Sciences, UCB Pharma S.A., Belgium

    Flash 8 – Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products
    Colin Clarke, NIBRT, Republic of Ireland

    Flash 9 –
    Using a cell receptor knock-out strategy to enable stable expression of cytotoxic envelope glycoproteins for lentiviral vector production
    Rodrigo Nogueira, iBET- Instituto de Biologia Experimental e Tecnológica, Portugal

    Flash 10 – Endogenous BiP reporter system for simultaneous identification of ER stress and antibody production in Chinese hamster ovary cells
    Jae Seong Lee, Ajou University, Korea (South, Republic Of)

    10:30 - 11:00 Coffee Break at Exhibition
    11:00 – 12:30 Scientific Session: Adaptive manufacturing: engineering quality into your process (part I)
    Chairpersons:
    Anne Tolstrup, AbtBioConsult, Denmark
    Laura Palomares, IBT-UNAM, Mexico

    INV 8 - The Application of Mechanistic Models Combined with Statistical Approaches Including Multivariate Visualization and Bayesian Methods to Enable Rapid Process Understanding
    Gene Schaefer, NIIMBL, United States

    O 16 – Next-gen glycoengineering: combining cellular and metabolic engineering to fine-tune mAb β1,4 galactosylation
    Apostolos Tsopanoglou, University College Dublin, Republic of Ireland

    O 17 – Knowing more from less: a microfluidic toolbox for at-line monitoring of bioprocesses
    Inês Pinto, Science for Life Laboratory & KTH Royal Institute of Technology, Sweden

    O 18 – Accurate identification of transgene integration sites and their structure by Cas9 targeted nanopore sequencing in CHO cells
    Klaus Leitner, Austrian Centre of Industrial Biotechnology (acib), BOKU, Austria

    Flash 11 – Successful Transfer of Raman Models from Ambr®250 high-throughput systems to larger Scale Stirred Tank Bioreactors
    Jens Traenkle, Bayer, Germany

    Flash 12 – Modular mini-factories for the automated and scalable production of ATMPs
    Mario Graeve, Fraunhofer, Germany

    Flash 13 – Rapid assessment of Aggregation of Biologics in different matrices and from Upstream and Downstream Development Process Stages
    Aris Perrou, PAIA Biotech GmbH, Germany
    12:30 - 14:30 Lunch at Lunch Hall
    Dessert and coffee (will be served at Exhibition Hall)
    14:30 - 16:00 Poster Session II (at Exhibition Hall)
    16:00 – 17:30

    Scientific Session: Challenges and Marvels of Bioprocess Intensification (part I)
    Chairpersons:
    Chetan Goudar, Amgen, USA
    Paulo Fernandes, Orchad, Uk
    Stefanos Grammatikos, UCB, Belgium

    16:00-16:25

    INV 9  - Process Intensification Opportunities, Challenges and Solutions: Product Quality, Harvest and Scale Up Considerations for Intensified Processes
    Bassem Bem Yahia, UCB Pharma, Belgium

    16:25-16:40

    O 19 - Process intensification and connected processing for robust, cost effective, and fast manufacturing of monoclonal antibodies
    Sanket Jadhav, Sartorius, Netherlands & Abijar Bhori, Enzene Biosciences, Pune, India

    16:40-16:55

    O 20 - Overcoming product retention in TFF-based perfusion cell cultures by using low shear magnetically levitating pumps
    Magdalena Pappenreiter, Bilfinger Life Science GmbH, Innovation Management; University of Natural Resources and Life Sciences (BOKU), Austria

    16:55-17:10

    O 21 - Migrating a months-long perfusion process to intensified fed-batch
    Lena Thoring, FyoniBio GmbH, Germany

    17:10-17:35

    INV 10  - Enabling Intensified Bioprocesses At Scale

    Daniel Karst, Biogen International GmbH, Switzerland

    17:30 - 18:00 Announcement & Networking Activities
    18:00 – 21:00 Social Event & Cocktail
  • 9:00 - 10:00 Keynote Lecture
    Raymond J. Deshaies, Amgen Research, United States
    Multispecificity – the future of molecular medicines
     10:00 - 10:30 TOP 10 Finalists - Poster Prize Flash Presentations
    The 10 Top Finalists - selected during Posters sessions I and II by the jury will be invited to present their poster
    10:30 - 11:30 POSTER SESSION III & Coffee Break at Exhibition
    11:30 – 12:30

    Scientific Session: Adaptive manufacturing: engineering quality into your process (part II)
    Chairpersons:
    Anne Tolstrup, AbtBioConsult, Denmark
    Laura Palomares, IBT-UNAM, Mexico

    11:30-12:00

    INV 11 - Next-generation, feedback responsive cell factories for recombinant protein manufacturing
    Laura Segatori, Rice University, United States

    12:00-12:15

    O 22 – Identification and Control of Novel Waste Inhibitory Metabolites In CHO Cell-Cultures
    Seongkyu Yoon, University of Massachustts Lowell, United States

    12:15-12:30

    O 23 – State-of-the-art strategies for adeno-associated virus product homogeneity assessment
    Marco Radukic, Biofidus AG / Bielefeld University, Germany

    12:30 - 14:30 Lunch at Lunch Hall
    Dessert and coffee (will be served at Exhibition Hall)
    14:30 – 16:00

    Scientific Session: Challenges and Marvels of Bioprocess Intensification (part II)
    Chairpersons:
    Chetan Goudar, Amgen, USA
    Paulo Fernandes, Orchad, Uk
    Stefanos Grammatikos, UCB, Belgium

    14:30-14:45

    O 24 – Optimization of continuous HIV-1 Gag virus-like particles (VLPs) harvest using an alternative perfusion approach
    Jesus Lavado, Universitat Autònoma de Barcelona (UAB), Spain

    14:45-15:00

    O 25 – The perks of innovating influenza VLP-based vaccine production
    Antonio Roldao, IBET & ITQB-NOVA, Portugal

    15:00-15:15

    O 26 – Cell Therapy Process Development with a 2 ml Continuous Perfusion Bioreactor
    Kevin Lee, Erbi Biosystems Inc., United States

    15:15-15:30

    O 27 – Ultracentrifugation for AAV manufacturing: non-linear scale-up improves quality & scalability
    Duarte Martins, Takeda, Austria

    15:30-15:35

    Flash 14 – Intensify Viral Vector Manufacturing Using Tangential Flow Depth Filtration (TFDF) platform
    Rachel Legmann, Repligen corp, United States

    15:35-15:40

    Flash 15 – A scalable bioprocess strategy for rAAV2 production using a stable cell line system
    Jose Escandell, iBET, Portugal

    15:40-15:45

    Flash 16 – Establishment of two suspension adapted stable packaging cell lines for scalable lentivirus production
    Maximilian Klimpel, CSL Behring Innovation GmbH, Germany

    15:45-15:50

    Flash 17 – Integrated process for the production and purification of therapeutic mesenchymal stromal cell-derived extracellular vesicles
    Ana Fernandes-Platzgummer, Instituto Superior Técnico, Univ Lisboa, Portugal

    16:00 - 17:00 Keynote Lecture
    Robert Deans, Synthego, United States
    Engineering Biology for future medicines
    17:30 - 18:00 ESACT Medals Ceremony
    The ESACT Medals are attributed to ESACT members in recognition of their contribution to ESACT activities.
    In 2022 Roland Wagner, Yvonne Genzel and Amine Kamen will be awarded with ESACT medals.

    ESACT 2022 Poster Prize Announcements
    CLOSING CEREMONY
    18:00 TRANSFER TO CONGRESS DINNER
    19:00 – 22:00 CONGRESS DINNER

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