AUDITORIUM I - ROOM
16:30 - 17:00 | ESACT 2022 Opening Session Paula Alves (ESACT) |
17:00-18:00 |
ESACT Innovation Award Lecture ESACT Innovation Award Lecture: Ambr15; how it happened and what was important |
18:00 – 19:20 |
Scientific Session: Bio breakthroughs INV 1 - Manipulating exosome biogenesis to enhance productivity of recombinant cell lines producing engineered exosome therapeutics INV 2 - Innovating the Manufacturing of Human Mesenchymal Stromal Cells (MSC) and MSC-derived Products through Bioengineering O 1 - Preservation of critical quality attributes in 3D bioprinted cell-based structures by using natural hydrogels O 2 - Turning an old medicine into a new therapeutical candidate: from erythropoietin to a novel hyperglycosylated, non-erythropoietic but neuroprotective analogue O 3 - Systems-level discovery of quality attributes and candidate pathways for optimized production of human pluripotent stem cell-derived cardiomyocytes O 4 - Human stem-cell based models to study innate immunity and neuroinflammation in the central nervous system |
19:20 – 19:45 |
Exhibitors Reception at the Exhibition Hall Introduction to The Porto wine |
9:00 - 10:00 | Keynote Lecture Botond Roska, Institute of Molecular and Clinical Ophthalmology Basel (IOB), Switzerland Restoring vision using optogenetic therapy |
10:00 - 10:35 |
Poster Student Highlights Nusa Pristovsek, ESACT Frontiers & Novo Nordisk, Denmark |
10:35 - 11:00 | Coffee Break at Exhibition |
11:00 – 12:30 |
Scientific Session: Data, Data, Data: how to get it and how to use it INV 3 - What can extracellular data tell us about intracellular pathways? INV 4 - Bioprocessing in the Digital Age: from Process Models, through the Integration of Machine Learning, to Digital Twins O 6 – Biomarker identification for in silico performance prediction of CHO cell lines expressing complex therapeutic Abs O 7 – On Digital Bioprocessing and Manufacturing Intelligence: Application of Process Analytical Technology and data analytics for upstream process development and intensification O 8 – Bioprocess digital twins for biomanufacturing 4.0 |
12:30 - 14:30 | Lunch at Lunch Hall Dessert and coffee (will be served at Exhibition Hall) |
14:30-16:00 | Poster Session I (at Exhibition Hall) |
16:00 – 17:30 |
Scientific Session: Beyond Evolution INV 5 - CAR T-cell immunotherapy of solid tumours: Parallel learning from the clinic and lab O 9 – Blueprint from nature: Multi-omics comparison of CHO and plasma cells unveils novel cell engineering targets to improve productivity O 10 – Enabling large therapeutic gene delivery: improving dual AAV vector-intein mediated systems O 11 – Theranostic cells for detection and counteraction of infections by rewiring cellular host defense pathways O 12 – Viral protease-based molecular switches for drug discovery and synthetic biology applications Flash 1 – Expanding The Design Space of Synthetic Promoters for CHO Cell Engineering Using Next-Generation Sequencing Flash 2 – Multiplexed engineering CHO cells to produce recombinant IgGs with desirable N-glycans via targeted integration |
17:30 - 18:00 | Coffee Break at Exhibition |
18:00 – 19:30 |
Scientific Session: Molecular Cell Surgery INV 6 - Turning Genes into Medicines: Prospects and Problems in Development of a Novel Class of Therapeutics INV 7 - Guiding mRNA-LNP drug products from early R&D programs to the market – Scale up and production of mRNA LNPs O 13 – Repairing the repairers: Stabilizing the CHO genome and protein production by editing DNA repair O 14 – Influenza A virus-derived defective interfering particles for antiviral treatment O 15 – An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells Flash 3 – Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease Flash 4 – Rational development of recombinant CHO cells based on histone analysis: Identification and experimental validation of stable integration sites |
19:30-21:00 | Poster Viewing plus drinks (at Exhibition Hall) |
9:00 - 10:00 | Keynote Lecture Hildegard Büning, Hannover Medical School, Germany Gene Therapy - a new class of medicine |
10:00 - 10:30 |
Selected Flash Presentations Session Chairpersons: Emma Petiot, 3d.FAB/UCBL, France Niall Barron, NIBRT, Ireland
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10:30 - 11:00 | Coffee Break at Exhibition |
11:00 – 12:30 | Scientific Session: Adaptive manufacturing: engineering quality into your process (part I) Chairpersons: Anne Tolstrup, AbtBioConsult, Denmark Laura Palomares, IBT-UNAM, Mexico INV 8 - The Application of Mechanistic Models Combined with Statistical Approaches Including Multivariate Visualization and Bayesian Methods to Enable Rapid Process Understanding Gene Schaefer, NIIMBL, United States O 16 – Next-gen glycoengineering: combining cellular and metabolic engineering to fine-tune mAb β1,4 galactosylation Apostolos Tsopanoglou, University College Dublin, Republic of Ireland O 17 – Knowing more from less: a microfluidic toolbox for at-line monitoring of bioprocesses Inês Pinto, Science for Life Laboratory & KTH Royal Institute of Technology, Sweden O 18 – Accurate identification of transgene integration sites and their structure by Cas9 targeted nanopore sequencing in CHO cells Klaus Leitner, Austrian Centre of Industrial Biotechnology (acib), BOKU, Austria Flash 11 – Successful Transfer of Raman Models from Ambr®250 high-throughput systems to larger Scale Stirred Tank Bioreactors Jens Traenkle, Bayer, Germany Flash 12 – Modular mini-factories for the automated and scalable production of ATMPs Mario Graeve, Fraunhofer, Germany Flash 13 – Rapid assessment of Aggregation of Biologics in different matrices and from Upstream and Downstream Development Process Stages Aris Perrou, PAIA Biotech GmbH, Germany |
12:30 - 14:30 | Lunch at Lunch Hall Dessert and coffee (will be served at Exhibition Hall) |
14:30 - 16:00 | Poster Session II (at Exhibition Hall) |
16:00 – 17:30 |
Scientific Session: Challenges and Marvels of Bioprocess Intensification (part I) INV 9 - Process Intensification Opportunities, Challenges and Solutions: Product Quality, Harvest and Scale Up Considerations for Intensified Processes O 19 - Process intensification and connected processing for robust, cost effective, and fast manufacturing of monoclonal antibodies O 20 - Overcoming product retention in TFF-based perfusion cell cultures by using low shear magnetically levitating pumps O 21 - Migrating a months-long perfusion process to intensified fed-batch INV 10 - Enabling Intensified Bioprocesses At Scale Daniel Karst, Biogen International GmbH, Switzerland |
17:30 - 18:00 | Announcement & Networking Activities |
18:00 – 21:00 | Social Event & Cocktail |
9:00 - 10:00 | Keynote Lecture Raymond J. Deshaies, Amgen Research, United States Multispecificity – the future of molecular medicines |
10:00 - 10:30 | TOP 10 Finalists - Poster Prize Flash Presentations The 10 Top Finalists - selected during Posters sessions I and II by the jury will be invited to present their poster |
10:30 - 11:30 | POSTER SESSION III & Coffee Break at Exhibition |
11:30 – 12:30 |
Scientific Session: Adaptive manufacturing: engineering quality into your process (part II) INV 11 - Next-generation, feedback responsive cell factories for recombinant protein manufacturing O 22 – Identification and Control of Novel Waste Inhibitory Metabolites In CHO Cell-Cultures O 23 – State-of-the-art strategies for adeno-associated virus product homogeneity assessment |
12:30 - 14:30 | Lunch at Lunch Hall Dessert and coffee (will be served at Exhibition Hall) |
14:30 – 16:00 |
Scientific Session: Challenges and Marvels of Bioprocess Intensification (part II) O 24 – Optimization of continuous HIV-1 Gag virus-like particles (VLPs) harvest using an alternative perfusion approach O 25 – The perks of innovating influenza VLP-based vaccine production O 26 – Cell Therapy Process Development with a 2 ml Continuous Perfusion Bioreactor O 27 – Ultracentrifugation for AAV manufacturing: non-linear scale-up improves quality & scalability Flash 14 – Intensify Viral Vector Manufacturing Using Tangential Flow Depth Filtration (TFDF) platform Flash 15 – A scalable bioprocess strategy for rAAV2 production using a stable cell line system Flash 16 – Establishment of two suspension adapted stable packaging cell lines for scalable lentivirus production Flash 17 – Integrated process for the production and purification of therapeutic mesenchymal stromal cell-derived extracellular vesicles |
16:00 - 17:00 | Keynote Lecture Robert Deans, Synthego, United States Engineering Biology for future medicines |
17:30 - 18:00 | ESACT Medals Ceremony The ESACT Medals are attributed to ESACT members in recognition of their contribution to ESACT activities. In 2022 Roland Wagner, Yvonne Genzel and Amine Kamen will be awarded with ESACT medals. ESACT 2022 Poster Prize Announcements CLOSING CEREMONY |
18:00 | TRANSFER TO CONGRESS DINNER |
19:00 – 22:00 | CONGRESS DINNER |